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Mechanistic issues concerning cancer prevention by tea catechins
Author(s) -
Yang Chung S.,
Wang Hong
Publication year - 2011
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201100036
Subject(s) - cancer , cancer prevention , carcinogenesis , camellia sinensis , angiogenesis , biology , cancer research , apoptosis , signal transduction , cell growth , cancer cell , in vivo , animal studies , pharmacology , bioinformatics , biochemistry , microbiology and biotechnology , genetics , endocrinology , botany
The cancer preventive activities of tea ( Camellia sinensis , Theaceae) have been demonstrated in animal models for cancers at different organ sites and suggested by some epidemiological studies. Many mechanisms for cancer prevention have been proposed based on studies in cell lines, which demonstrated the modulation of signal transduction and metabolic pathways by (−)‐epigallocatechin‐3‐gallate (EGCG), the most abundant and active polyphenol in green tea. These molecular events may result in cellular changes, such as enhancement of apoptosis, suppression of cell proliferation, and inhibition of angiogenesis. Nevertheless, it is not known whether these are the molecular mechanisms of inhibition of carcinogenesis in animals and humans. This article discusses the key issues involved in extrapolating results from cell line studies to mechanistic information in vivo and in translating animal studies to human cancer prevention.