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Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin
Author(s) -
Kakkar Vandita,
Singh Sukhjit,
Singla Dinesh,
Kaur Indu Pal
Publication year - 2011
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201000310
Subject(s) - curcumin , bioavailability , solid lipid nanoparticle , pharmacokinetics , pharmacology , oral administration , chemistry , in vivo , drug , particle size , solubility , nanoparticle , chromatography , materials science , nanotechnology , medicine , organic chemistry , microbiology and biotechnology , biology
Scope : Curcumin, a molecule with pluripharmacological properties, was loaded into solid lipid nanoparticles (SLNs) with a view to improve its oral bioavailability (BA). Methods and results : Curcumin‐loaded solid lipid nanoparticles (C‐SLNs) with an average particle size of 134.6 nm and a total drug content of 92.33±1.63% was produced using a microemulsification technique. The particles were spherical in shape, with high drug entrapment of 81.92±2.91% at 10% drug loading. The in vitro release was predominantly by diffusion phenomenon and was prolonged up to 7 days. No significant variation in particle size and curcumin content of C‐SLNs was observed, upon storage, over a period of 12 months at 5±3°C. In vivo pharmacokinetics performed after oral administration of C‐SLNs (50, 25, 12.5 and 1 mg/kg dose) and (free) solubilized curcumin (C‐S; 50 mg/kg), using a validated LC‐MS/MS method in rat plasma revealed significant improvement (at p <0.05) in BA (39 times at 50 mg/kg; 155 times at 1 mg/kg; and, 59 and 32 times at 12.5 and 25 mg/kg, respectively) after administration of C‐SLNs at all the doses with respect to C‐S. Conclusions : Enhanced and reliable BA will help in establishing its therapeutic usefulness especially for neurodegenerative and cancerous disorders in humans.