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High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin
Author(s) -
Yamane Takumi,
KobayashiHattori Kazuo,
Oishi Yuichi,
Takita Toshichika
Publication year - 2010
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201000022
Subject(s) - endocrinology , medicine , adiponectin , dermis , messenger rna , hyaluronan synthase , transforming growth factor , chemistry , biology , insulin , insulin resistance , biochemistry , enzyme , gene , anatomy
Abstract Although it is known that nutritional conditions affect the skin function, little information is available on the effect of a high‐fat (HF) diet on skin. In this study, Sprague–Dawley rats were fed HF diets for 28 days, and we investigated the effect of this diet on type I tropocollagen and hyaluronan in rat skin. The HF diets reduced the levels of type I tropocollagen, COL1A1 mRNA, hyaluronan, and rat hyaluronan synthase ( rhas ) 2 mRNA, which play a primary role in hyaluronan synthase in the dermis. However, rhas3 mRNA level in the skin was increased. The HF diets also decreased the skin mRNA expression of transforming growth factor ( TGF )‐ β1 , which enhances the expression of COL1A1 and rhas2 mRNA and decreases rhas3 mRNA expression, and decreased the hepatic mRNA expression of insulin‐like growth factor (IGF)‐I , which enhances COL1A1, rhas2, and TGF ‐ β1 mRNA expression. The serum level of adiponectin, which promotes the syntheses of type I collagen and hyaluronan, was decreased in the HF diet groups. These findings suggest that an HF diet reduces the levels of type I tropocollagen and hyaluronan in the skin by suppressing the action of TGF‐β1, IGF‐I and adiponectin, and these effects are deleterious for skin function.