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Molecular mechanisms of membrane transport of vitamin E
Author(s) -
Takada Tappei,
Suzuki Hiroshi
Publication year - 2010
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.200900481
Subject(s) - atp binding cassette transporter , efflux , scavenger receptor , transporter , microbiology and biotechnology , multidrug resistance associated protein 2 , micronutrient , calcitriol receptor , secretion , biology , biochemistry , vitamin , regulator , chemistry , antioxidant , receptor , gene , cholesterol , lipoprotein , organic chemistry
Vitamin E is an essential fat‐soluble micronutrient for higher mammals and functions as an antioxidant for lipids and also as a regulator of gene expression and a modulator of cell signaling and proliferation. To exert its physiological functions, vitamin E must achieve an appropriate disposition throughout the body via several processes, such as intestinal absorption, uptake and efflux in peripheral tissues and biliary secretion. In this review, we mainly discuss membrane proteins involved in these transport processes (ATP‐binding cassette transporter A1, scavenger receptor class B type I, Niemann‐Pick C1‐like 1 and multidrug resistance 3) and vitamin E‐mediated regulation of their expression.