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The Japanese toxicogenomics project: Application of toxicogenomics
Author(s) -
Uehara Takeki,
Ono Atsushi,
Maruyama Toshiyuki,
Kato Ikuo,
Yamada Hiroshi,
Ohno Yasuo,
Urushidani Tetsuro
Publication year - 2010
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.200900169
Subject(s) - toxicogenomics , hazardous waste , profiling (computer programming) , risk assessment , computational biology , risk analysis (engineering) , engineering , biology , computer science , medicine , gene expression , gene , computer security , genetics , operating system , waste management
Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted approach for identifying chemicals with potential safety problems. Gene expression profiling is expected to identify the mechanisms that underlie the potential toxicity of chemicals. This technology has also been applied to identify biomarkers of toxicity to predict potential hazardous chemicals. Ultimately, toxicogenomics is expected to aid in risk assessment. The following discussion explores potential applications and features of the Japanese Toxicogenomics Project.