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Enteral nutrition in adult Crohn's disease: Present status and perspectives
Author(s) -
Dupont Benoît,
Dupont Claire,
Justum AnneMarie,
Piquet MarieAstrid,
Reimund JeanMarie
Publication year - 2008
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.200800093
Subject(s) - medicine , azathioprine , parenteral nutrition , crohn's disease , methotrexate , disease , concomitant , malnutrition , gastroenterology , enteral administration , intensive care medicine , mercaptopurine , surgery
Enteral nutrition has long been a therapeutic alternative often used in adult Crohn's disease patients to obtain remission or clinical response, especially in those not responding to conventional therapy such as corticosteroids. However, the increasing use of immunosuppressors (6‐mercaptopurine and azathioprine, methotrexate, etc .), and the advent of biotherapies (especially anti‐tumor necrosis factor‐alpha (TNF‐α) antibodies), decreased its use in adult Crohn's disease. Nevertheless, enteral nutrition remains of interest in patients presenting concomitant malnutrition (in particular in nonobstructed patients needing surgery), or in those intolerant or who failed to other therapeutics. In addition, recent studies provide data indicating its potential interest in maintenance therapy in selected patients groups. Finally, future research (in particular in the field of immuno‐ or pharmaconutrition) could lead to enteral formula's improvement, with better tolerance and acceptability, as well as increased efficacy.