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Time‐course regulation of quercetin on cell survival/proliferation pathways in human hepatoma cells
Author(s) -
GranadoSerrano Ana Belén,
Angeles Martín María,
Bravo Laura,
Goya Luis,
Ramos Sonia
Publication year - 2008
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.200700203
Subject(s) - microbiology and biotechnology , kinase , protein kinase b , mapk/erk pathway , pi3k/akt/mtor pathway , protein kinase c , signal transduction , protein kinase a , cell growth , quercetin , biology , ask1 , phosphatidylinositol , mitogen activated protein kinase kinase , chemistry , biochemistry , antioxidant
Quercetin, a dietary flavonoid, has been shown to possess anticarcinogenic properties, but the precise molecular mechanisms of action are not thoroughly elucidated. This study was aimed at investigating the time‐course regulation effect of quercetin on survival/proliferation pathways in a human hepatoma cell line (HepG2). Quercetin induced a significant time‐dependent inactivation of the major survival signaling proteins, i. e. , phosphatidylinositol 3‐kinase (PI 3‐kinase)/protein kinase B (AKT), extracellular regulated kinase (ERK), protein kinase C‐α (PKC‐α), in concert with a time‐dependent activation of key death‐related signals: c‐jun amino‐terminal kinase (JNK) and PKC‐δ. These data suggest that quercetin exerts a tight regulation of survival/proliferation pathways that requires the integration of different signals and persists over time, being the balance of these regulatory signals what determines the fate of HepG2 cells.