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The involvement of oxidative stress in ochratoxin A and fumonisin B 1 toxicity in rats
Author(s) -
Domijan AnaMarija,
Peraica Maja,
Vrdoljak Ana Lucić,
Radić Božica,
Žlender Vilim,
Fuchs Radovan
Publication year - 2007
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.200700079
Subject(s) - malondialdehyde , ochratoxin a , catalase , oxidative stress , kidney , chemistry , nephrotoxicity , mycotoxin , toxicity , fumonisin b1 , fumonisin , lipid peroxidation , pharmacology , endocrinology , medicine , food science , biochemistry , biology , organic chemistry
The aim of this study was to find out whether very low doses of nephrotoxic and hepatotoxic mycotoxins ochratoxin A (OTA) and fumonisin B 1 (FB 1 ) induce oxidative stress in rat kidney and liver and whether their effect is synergistic. Rats were treated orally with OTA (5 ng/kg b.w. and 50 μg/kg b.w.) and FB 1 (200 ng/kg b.w. and 50 μg/kg b.w.), or their combinations. Malondialdehyde (MDA) and protein carbonyls (PCs) concentration in kidney was affected with lower dose of OTA than in liver ( p < 0.05). FB 1 did not affect MDA and PCs concentrations in the liver, while in the kidney both FB 1 doses increased MDA concentration ( p < 0.05). The combination of the lower doses of OTA + FB 1 increased the MDA and PCs concentration both in the liver and the kidney, compared to controls and animals treated with respective doses of mycotoxins ( p < 0.05). The combinations of mycotoxins reduced the catalase activity only in the kidney when compared to controls ( p < 0.05). In contrast to the increased kidney concentrations of MDA and PCs even with very low doses of OTA and FB 1 , the activity of catalase and SOD does not change. Combinations of OTA + FB 1 affected almost all parameters, which indicates their potential to produce oxidative damage.