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Effect of cranberry juice on eradication of Helicobacter pylori in patients treated with antibiotics and a proton pump inhibitor
Author(s) -
Shmuely Haim,
Yahav Jacob,
Samra Zmira,
Chodick Gabriel,
Koren Rivka,
Niv Yaron,
Ofek Itzhak
Publication year - 2007
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.200600281
Subject(s) - placebo , helicobacter pylori , amoxicillin , gastroenterology , medicine , omeprazole , cranberry juice , clarithromycin , proton pump inhibitor , antibiotics , breath test , biology , microbiology and biotechnology , alternative medicine , urinary system , pathology
Cranberry constituents are known to exert anti‐adhesion activity on H. pylori in vitro. To determine their possible additive effect to triple therapy with omeprazole, amoxicillin and clarithromycin (OAC), a double‐blind randomized clinical study was carried out. One‐hundred‐seventy‐seven patients with H. pylori infection treated with OAC for 1 week were randomly allocated to receive 250 mL of either cranberry juice (cranberry‐OAC, n = 89) or placebo beverage (placebo‐OAC, n = 88) twice daily and only cranberry juice or placebo beverage for the next 2 weeks. Treatment outcome was determined with the 13 C urea breath test ( 13 C‐UBT). An additional control group consisted of patients referred to the same center during the same period who were treated with OAC alone for 1 week (non‐placebo‐OAC, n = 712). Overall, the rate of H. pylori eradication ( 13 C‐UBT < 3.5) was 82.5%, with no statistically significant difference among the three arms. Analysis by gender revealed that for female subjects, the eradication rate was higher in the cranberry‐OAC arm ( n = 42, 95.2%) than in the placebo‐OAC arm ( n = 53, 86.8%) and significantly higher than in the non‐placebo‐OAC group ( n = 425, 80%; p = 0.03). For males, the rate was nonsignificantly lower in the cranberry‐OAC arm (n = 35, 73.9%) than in the placebo‐OAC arm ( n = 45, 80.0%) and non‐placebo‐OAC group ( n = 287, 85.0%). These results suggest that the addition of cranberry to triple therapy improves the rate of H. pylori eradication in females.