Premium
Association of metabolic syndrome risk factors with selected markers of oxidative status and microinflammation in healthy omnivores and vegetarians
Author(s) -
Šebeková Katarína,
Boor Peter,
Valachovičová Martina,
Blažíček Pavol,
Parrák Vojtech,
Babinská Katarína,
Heidland August,
KrajčovičováKudláčková Marica
Publication year - 2006
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.200500170
Subject(s) - medicine , endocrinology , metabolic syndrome , oxidative stress , vitamin c , vitamin b12 , biology , obesity
Conditions predisposing to metabolic syndrome (MetS) are associated with increased oxidative stress and inflammation. We studied, in vegetarians ( n = 90) and omnivores ( n = 46), the impact of the dietary regimen on the occurrence of MetS risk factors (RFs: BMI, blood pressure, glucose metabolism and lipid profile) in relation to oxidative status (advanced glycation end products (AGEs), advanced oxidation protein products (AOPPs), malondialdehyde, ferric reducing ability of plasma, vitamins A, E, C, β‐carotene and superoxide dismutase activity) and microinflammation (C‐reactive protein, leukocytes and neopterin). The proportion of subjects without/positive for one or two MetS RFs was comparable between the groups. From the components of MetS only immunoreactive insulin levels differed significantly (95% CI: omnivores: 5.0–7.1 μU/mL, vegetarians: 4.5–5.4, p = 0.03). Omnivores had lower AOPP (omnivores: 0.29–0.36 μmol/g albumin, vegetarians: 0.36–0.52, p = 0.01) and β‐carotene levels than vegetarians, they consumed more calories, proteins, fat and saturated fatty acids, and less fibres, β‐carotene and vitamin C. Multiple regression analysis revealed vitamin E and AOPP levels as the most important independent determinants of MetS RFs. The vegetarian diet seems to exert beneficial effects on MetS RFs associated microinflammation. Whether the vegetarian diet may counteract the deleterious effects of elevated AOPPs and AGEs, remains to be elucidated.