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Numerical simulation of a two‐compartmental fractional model in pharmacokinetics and parameters estimation
Author(s) -
Qiao Yanli,
Xu Huanying,
Qi Haitao
Publication year - 2021
Publication title -
mathematical methods in the applied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 65
eISSN - 1099-1476
pISSN - 0170-4214
DOI - 10.1002/mma.7511
Subject(s) - fractional calculus , mathematics , laplace transform , particle swarm optimization , numerical analysis , mathematical optimization , mathematical analysis
Compartmental model is the classic and widely used approach in pharmacokinetics. Recently, fractional calculus is introduced to describe the time course of drugs in human body which follow the anomalous diffusion mechanism. To consider the different fractional order transmission process, the two‐compartmental fractional model has been proposed and studied. And it will be of great significance to find out a simple and efficient numerical method to solve the model and estimate model parameters. This work investigates two numerical methods of the two‐compartmental fractional model using finite difference schemes, which are based on the shifted Grünwald–Letnikov approximate formula and L 1 formula, respectively. The hybrid Nelder–Mead simplex search and particle swarm optimization, denoted as NMSS–PSO, is provided to estimate the fractional model parameters. Comparison between the numerical solution and the solution by the numerical inverse Laplace transform method establishes the validity of the developed numerical algorithms. Then the influence of the order of fractional derivative on the drug amount in human body is also discussed. Finally, the two‐compartmental fractional model is applied to fit the amiodarone pharmacokinetics data based on the NMSS–PSO algorithms. This work will be of importance for the development of fractional pharmacokinetics.