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A theoretical model of chronic hepatitis B virus with suboptimal adherence and drug resistance
Author(s) -
Manda Edna,
Chirove Farai
Publication year - 2020
Publication title -
mathematical methods in the applied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 65
eISSN - 1099-1476
pISSN - 0170-4214
DOI - 10.1002/mma.6829
Subject(s) - medicine , immune system , virus , drug , drug resistance , hepatitis b virus , chronic hepatitis , hepatitis , virology , immunology , pharmacokinetics , pharmacology , biology , microbiology and biotechnology
In this paper, we formulate and analyze a within‐host hepatitis B viral theoretical mathematical model for hepatitis B virus infection in the chronic phase of liver cancer with suboptimal adherence and drug resistance. The model incorporates hepatocytes, hepatitis B virus, immune cells, and cytokine dynamics using a system of ordinary differential equations. Treatment was captured using efficacy functions replicating the realistic pharmacokinetics properties of two drugs, one of which is administered intravenously and the other orally. Our results suggest that natural drug resistance increases the hepatitis B virus burden more than suboptimal adherence to drugs from both monotherapies and combined therapies. The results also suggest that the inclusion of both immune cells and cytokine responses is essential and that combination therapies are more significant in reducing hepatitis B virus infection than monotherapies.