Premium
Optimal vaccination and control strategies against dengue
Author(s) -
Fischer Anne,
Chudej Kurt,
Pesch Hans Josef
Publication year - 2019
Publication title -
mathematical methods in the applied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 65
eISSN - 1099-1476
pISSN - 0170-4214
DOI - 10.1002/mma.5594
Subject(s) - vaccination , dengue fever , mass vaccination , outbreak , mathematics , optimal control , imperfect , virology , medicine , mathematical optimization , linguistics , philosophy
This article focuses on the mathematical modelling of a disease outbreak of dengue fever. A cost‐efficient fighting strategy, which simultaneously uses vaccination, application of insecticides to adult and aquatic mosquitoes, and an approach to decrease the number of man‐made breeding places for the mosquitoes, is computed using optimal control. Vaccination includes a paediatric vaccination and an imperfect random mass vaccination with waning immunity.