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Dynamic model of integrated cardiovascular and respiratory systems
Author(s) -
Lee RongMao,
Tsai NanChyuan
Publication year - 2013
Publication title -
mathematical methods in the applied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 65
eISSN - 1099-1476
pISSN - 0170-4214
DOI - 10.1002/mma.2748
Subject(s) - extracorporeal circulation , control theory (sociology) , controller (irrigation) , extracorporeal membrane oxygenation , computer science , cardiology , medicine , simulation , control engineering , engineering , artificial intelligence , control (management) , agronomy , biology
A set of linear time‐variant dynamic models for the interactive respiratory/cardiovascular mechanism is constructed and analyzed in this work. By using equivalent electric circuits for heart/blood and lung/air subsystems, the dynamics of cardiovascular subsystem and respiration cycle are established. In order to verify the validity of the dynamic models, numerical simulations and analysis on heart–lung interactions, including the valvular closure incompetence and pulmonary obstruction, are presented and compared with the empirical reports in literature. The derived dynamics of heart–lung interactions can be realized and examined in the biomechanical and medical engineering fields. In addition, the dynamic models can also be used for the model‐based controller synthesis in medical instrumentations, for example, the extracorporeal membrane oxygenation, to retain the function of blood circulation and/or respiration by artificial intelligence. Copyright © 2013 John Wiley & Sons, Ltd.