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Identification of Cl(Ca) channel distributions in olfactory cilia
Author(s) -
Badamdorj Dorjsuren,
Edwards David A.,
French Donald A.,
Kleene Steven J.
Publication year - 2008
Publication title -
mathematical methods in the applied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 65
eISSN - 1099-1476
pISSN - 0170-4214
DOI - 10.1002/mma.1007
Subject(s) - cyclic nucleotide gated ion channel , cilium , ion channel , biophysics , chemistry , depolarization , physics , neuroscience , cyclic nucleotide , biology , biochemistry , nucleotide , microbiology and biotechnology , receptor , gene
Identification of detailed features of neuronal systems is an important challenge in the biosciences today. Transduction of an odor into an electrical signal occurs in the membranes of the cilia. The Cl(Ca) channels that reside in the ciliary membrane are activated by calcium, allow a depolarizing efflux of Cl − and are thought to amplify the electrical signal to the brain. In this paper, a mathematical model consisting of partial differential equations is developed to study two different experiments; one involving the interaction of the cyclic‐nucleotide‐gated (CNG) and Cl(Ca) channels and the other, the diffusion of Ca 2+ into cilia. This work builds on an earlier study (Mathematical modeling of the Cl(Ca) ion channels in frog olfactory cilia. Ph.D. Thesis , University of Cincinnati, Cincinnati, OH, 2006; Math. Comput. Modelling 2006; 43 :945–956; Biophys. J. 2006; 91 :179–188), which suggested that the CNG channels are clustered at about 0.28 of the length of a cilium from its open end. Closed‐form solutions are derived after certain reductions in the model are made. These special solutions provide estimates of the channel distributions. Scientific computation is also used. This preliminary study suggests that the Cl(Ca) ion channels are also clustered at about one‐third of the length of a cilium from its open end. Copyright © 2008 John Wiley & Sons, Ltd.