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Cover Picture: Could Adenosine Recognize its Receptors with a Stoichiometry Other than 1 : 1? (Mol. Inf. 8/2018)
Author(s) -
Deganutti Giuseppe,
Salmaso Veronica,
Moro Stefano
Publication year - 2018
Publication title -
molecular informatics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.481
H-Index - 68
eISSN - 1868-1751
pISSN - 1868-1743
DOI - 10.1002/minf.201880801
Subject(s) - adenosine receptor , g protein coupled receptor , adenosine , intermolecular force , cover (algebra) , receptor , stoichiometry , chemistry , computer science , stereochemistry , computational biology , molecule , biology , biochemistry , agonist , mechanical engineering , engineering , organic chemistry
The cover picture shows an allegoric representation of the human A 2A adenosine receptor (A 2A AR) while it is recognizing a second molecule of its endogenous effector adenosine (ado). Besides the conventional adenosine‐A 2A AR complex, our study proposes the possible formation of an intermolecular complex with stoichiometry of 2:1, as symbolically reported on the blackboard in background. The G protein coupled receptor (GPCRs) field is recently experiencing a prosperous scientific time, and our findings could add complexity to this already multifaceted and fascinating world. Details are discussed in the article by Giuseppe Deganutti, Veronica Salmaso, and Stefano Moro. For full text, please see DOI: 10.1002/minf.201800009