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Network‐based Approaches in Pharmacology
Author(s) -
Boezio Baptiste,
Audouze Karine,
Ducrot Pierre,
Taboureau Olivier
Publication year - 2017
Publication title -
molecular informatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.481
H-Index - 68
eISSN - 1868-1751
pISSN - 1868-1743
DOI - 10.1002/minf.201700048
Subject(s) - computer science , cheminformatics , drug discovery , context (archaeology) , drug , chemical space , computational biology , biological network , systems pharmacology , data science , bioinformatics , pharmacology , biology , paleontology
In drug discovery, network‐based approaches are expected to spotlight our understanding of drug action across multiple layers of information. On one hand, network pharmacology considers the drug response in the context of a cellular or phenotypic network. On the other hand, a chemical‐based network is a promising alternative for characterizing the chemical space. Both can provide complementary support for the development of rational drug design and better knowledge of the mechanisms underlying the multiple actions of drugs. Recent progress in both concepts is discussed here. In addition, a network‐based approach using drug‐target‐therapy data is introduced as an example.