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Repositioning of Endonuclear Receptors Binders as Potential Antibacterial and Antifungal Agents. Eptyloxìm: A Potential and Novel Gyrase B and Cytochrome Cyp51 Inhibitor
Author(s) -
Carrieri Antonio,
L'Abbate Maria,
Di Chicco Mariangela,
Rosato Antonio,
Carbonara Giuseppe,
Fracchiolla Giuseppe
Publication year - 2016
Publication title -
molecular informatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.481
H-Index - 68
eISSN - 1868-1751
pISSN - 1868-1743
DOI - 10.1002/minf.201600021
Subject(s) - dna gyrase , thiazole , antifungal , topoisomerase iv , chemistry , virtual screening , pharmacology , computational biology , stereochemistry , biochemistry , microbiology and biotechnology , biology , escherichia coli , drug discovery , gene
A novel class of antibacterial and antifungal agents is here identified by means of dockings and virtual screening techniques. Biological data proved the initial effort, formulated on the structure similarity of nuclear receptors binders with known quinolones or thiazole derivatives, to reposition PPARs agonists as likely bacterial type II topoisomerases inhibitors.