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An In Silico Classification Model for Putative ABCC2 Substrates
Author(s) -
Pinto Marta,
Trauner Michael,
Ecker Gerhard F.
Publication year - 2012
Publication title -
molecular informatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.481
H-Index - 68
eISSN - 1868-1751
pISSN - 1868-1743
DOI - 10.1002/minf.201200049
Subject(s) - multidrug resistance associated protein 2 , atp binding cassette transporter , multidrug resistance associated proteins , glutathione , biochemistry , xenobiotic , chemistry , abcg2 , transporter , glucuronate , progressive familial intrahepatic cholestasis , efflux , heme , biology , pharmacology , medicine , enzyme , gene , transplantation , liver transplantation
ABCC2 (MRP2; also known as cMOAT or cMRP) belongs to the adenosine triphosphate (ATP)-binding cassette (ABC) transporter superfamily, which represents a large family of transmembrane proteins that use the energy of ATP hydrolysis to transport a wide variety of physiological substrates across biological membranes.1 Phylogenetically, ABC transporters are classified into seven subfamilies of 49 transporter genes (ABCA to ABCG).2 The major physiological role of these transporters is to protect cells and tissues against xenobiotics. Consequently, they also play a critical role in the disposition of drugs and their metabolites, altering their pharmacokinetics and pharmacological profile.1