Premium
Mimicking Peptides… In Silico
Author(s) -
Floris Matteo,
Moro Stefano
Publication year - 2012
Publication title -
molecular informatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.481
H-Index - 68
eISSN - 1868-1751
pISSN - 1868-1743
DOI - 10.1002/minf.201100093
Subject(s) - peptidomimetic , in silico , computational biology , protein–protein interaction , drug discovery , structural bioinformatics , peptide , chemistry , bioinformatics , computer science , biology , protein structure , biochemistry , gene
Protein‐protein interactions (PPIs) play a central and crucial role in almost every cellular process. Understanding the structural basis of protein‐protein interactions can lead to the development of new drugs for treatment of various diseases. With this purpose, peptide‐based drug design (PBDD) has been extensively explored in the last few decades. Peptidomimetics are compounds which mimic the biological activity of peptides while offering the advantages of improving their pharmacokinetics profiles. In this review, we would like to summarize the state of the art of computational methods which have been recently introduced to design novel peptidomimetics involved in a therapeutically relevant protein‐protein recognition processes.