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Is the knowledge on tissue microcirculation important for microsurgeon?
Author(s) -
Kusza Krzysztof,
Siemionow Maria
Publication year - 2011
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.20927
Subject(s) - medicine , microcirculation , microsurgery , context (archaeology) , hemodynamics , ischemia , pathophysiology , anastomosis , intensive care medicine , surgery , cardiology , pathology , paleontology , biology
This review article outlines the importance of knowledge on the hemodynamics of microcirculatory responses during free tissue transfer procedures. Anatomy and pathophysiology of peripheral microcirculation are outlined in the context of its responses during microsurgical procedures submitted to ischemia and reperfusion injury. The factors influencing the patient's outcome such as neural, humoral, and muscular regulations and prostoglandins, kinins, nitric oxide actions, and so on are outlined. In addition, otherimportant factors influencing microcirculatory responses are discussed. Thegoal of this review article is to introduce nonsurgical factors independentof the microsurgeon's control which, via changes in microcirculatory hemodynamics, may contribute to free flap survival and final patient's outcomes. Thus, we hope that this overview of the pathophysiology of tissuemicrocirculation will help microsurgeons to monitor factors beyond control of vessel patency and technical aspects of microvascular anastomosis. © 2011 Wiley‐Liss, Inc. Microsurgery, 2011.