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Use of 1‐desamino‐8‐ D ‐arginine vasopressin in microsurgical reconstruction in a patient with von Willebrand's disease
Author(s) -
Mithani Suhail K.,
Davis Jared M.,
Rodriguez Eduardo D.
Publication year - 2011
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.20846
Subject(s) - medicine , vasopressin , surgery , microsurgery , thrombosis , von willebrand factor , nasal administration , von willebrand disease , anesthesia , platelet , immunology
A 19‐year‐old male patient with type 1 von Willebrand's disease underwent two separate superficial inferior epigastric artery free flap tissue transfers and three revision procedures for reconstruction of a postextirpative mid‐facial defect. Intravenous 1‐desamino‐8‐ D ‐arginine vasopressin (DDAVP) was administered as bleeding prophylaxis prior to incision for free tissue transfer. For each debulking procedure, DDAVP was administered by intranasal sprays in minutes prior to incision and redosed 12 and 24 hours postoperatively. There were no incidents of either thrombosis or bleeding. This outcome indicates that 0.3 μg/kg intravenous DDAVP may be effective as bleeding prophylaxis for patients with mild and quantitative defects in von Willebrand factor undergoing microvascular reconstruction. © 2011 Wiley‐Liss, Inc. Microsurgery, 2011.