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Regeneration and repair of peripheral nerves with different biomaterials: Review
Author(s) -
Siemionow Maria,
Bozkurt Mehmet,
Zor Fatih
Publication year - 2010
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.20799
Subject(s) - medicine , peripheral nerve , regeneration (biology) , nerve repair , microsurgery , epineurial repair , peripheral nerve injury , nerve guidance conduit , peripheral , surgery , nerve injury , anatomy , microbiology and biotechnology , biology
Abstract Peripheral nerve injury may cause gaps between the nerve stumps. Axonal proliferation in nerve conduits is limited to 10–15 mm. Most of the supportive research has been done on rat or mouse models which are different from humans. Herein we review autografts and biomaterials which are commonly used for nerve gap repair and their respective outcomes. Nerve autografting has been the first choice for repairing peripheral nerve gaps. However, it has been demonstrated experimentally that tissue engineered tubes can also permit lead to effective nerve repair over gaps longer than 4 cm repair that was previously thought to be restorable by means of nerve graft only. All of the discoveries in the nerve armamentarium are making their way into the clinic, where they are, showing great potential for improving both the extent and rate of functional recovery compared with alternative nerve guides. © 2010 Wiley‐Liss, Inc. Microsurgery, 2010.