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Development of a portocaval shunt using a small intestinal segment in rats
Author(s) -
Hata Toshiyuki,
Iwasaki Junji,
Hishikawa Shuji,
Fujimoto Yasuhiro,
Uemoto Shinji,
Kobayashi Eiji
Publication year - 2010
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.20751
Subject(s) - medicine , shunt (medical) , portacaval shunt , anastomosis , hepatic encephalopathy , surgery , superior mesenteric artery , portosystemic shunt , transjugular intrahepatic portosystemic shunt , sma* , inferior vena cava , trunk , portal hypertension , cirrhosis , biology , mathematics , combinatorics , ecology
The transjugular portosystemic shunt, widely used to treat portal hypertension today, may increase the risk of encephalopathy and reduce effective hepatic flow. To address these issues, a strategy to produce a portocaval shunt (PCS) with hepatic function using intestinal grafts was conceived, and rat models were developed. We transplanted ileal grafts from wild‐type and luciferase transgenic Lewis rats to wild‐type Lewis rats, anastomosing the graft mesenteric artery (SMA) and portal vein (PV) to the recipient PV trunk and inferior vena cava, respectively. Recipient survival was significantly longer in the partial PCS model, in which the graft SMA was anastomosed to the recipient PV trunk in an end‐to‐side fashion, than in the total PCS model, with the end‐to‐end anastomosis. In the partial PCS model, histological and luminescence analyses showed graft survival for 1 month. These results suggest that intestinal grafts can be maintained in the particular conditions required for our strategy. © 2010 Wiley‐Liss, Inc. Microsurgery, 2010.