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Investigation of reperfusion injury and ischemic preconditioning in microsurgery
Author(s) -
Wang Wei Zhong
Publication year - 2008
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.20587
Subject(s) - medicine , microsurgery , ischemia , surgery , reperfusion injury , ischemic injury , ischemic preconditioning
Ischemia/reperfusion (I/R) is inevitable in many vascular and musculoskeletal traumas, diseases, free tissue transfers, and during time‐consuming reconstructive surgeries in the extremities. Salvage of a prolonged ischemic extremity or flap still remains a challenge for the microvascular surgeon. One of the common complications after microsurgery is I/R‐induced tissue death or I/R injury. Twenty years after the discovery, ischemic preconditioning has emerged as a powerful method for attenuating I/R injury in a variety of organs or tissues. However, its therapeutic expectations still need to be fulfilled. In this article, the author reviews some important experimental evidences of I/R injury and preconditioning‐induced protection in the fields relevant to microsurgery. © 2008 Wiley‐Liss, Inc. Microsurgery, 2009.