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A dose‐effect relationship of Ginkgo biloba extract to nerve regeneration in a rat model
Author(s) -
Lin Haodong,
Wang Huan,
Chen Desong,
Gu Yudong
Publication year - 2007
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.20430
Subject(s) - medicine , ginkgo biloba , saline , sciatic nerve , regeneration (biology) , nerve conduction velocity , anesthesia , axon , electrophysiology , pharmacology , anatomy , biology , microbiology and biotechnology
The effect of Ginkgo biloba extract (EGb 50 ) on nerve regeneration and its dose–effect relationship was investigated in a rat model. Sciatic nerve transection and repair was done in 120 Sprague‐Dawley rats. The animals were divided into four groups and given normal saline, low‐dose EGb 50 (50 mg kg −1 d −1 ), moderate‐dose EGb 50 (100 mg kg −1 d −1 ), and high‐dose EGb 50 (200 mg kg −1 d −1 ), respectively. Electrophysiological, histological examinations, and functional evaluation were conducted at various postoperative intervals. Sensory regeneration distance, sciatic functional index (SFI), motor nerve conduction velocity, compound muscle action potential, axon regeneration index, and muscle mass were significantly higher in EGb 50 groups than in saline groups. All but SFI of those parameters were better in high‐dose group when compared with those in moderate‐ and low‐dose groups. EGb 50 has the effect of promoting regeneration of injured peripheral nerve.The higher the dose, the better the result. © 2007 Wiley‐Liss, Inc. Microsurgery, 2007.