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Chimerism and bone marrow based therapies in transplantation
Author(s) -
Siemionow Maria,
Nasir Serdar
Publication year - 2007
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.20395
Subject(s) - medicine , allotransplantation , bone marrow , microsurgery , bone marrow transplant , transplantation , bone marrow transplantation , pathology , surgery
Composite tissue allotransplantation holds a great potential for providing increased knowledge of anatomy and microsurgical experience for life‐enhancing reconstructions. Many transplant cases around the world have made this a clinical reality at the present time. Composite tissue allotransplants contain multiple tissue types, including bone, muscle, vessels, nerves, skin, and immune cells and bear a huge antigenic load. Although immunosuppressive drugs are applied successfully to prevent allograft rejection, their side effects pose a barrier to worldwide use. Bone marrow therapy in many tolerance induction protocols, therefore, provides a guide to reaching the target of permanent immunotolerance. Multiple studies suggest that bone marrow is immunomodulatory and may facilitate allograft acceptance. In this review, bone marrow based therapy protocols of clinical and experimental models are presented in two major categories: solid organ and composite tissue transplantation. © 2007 Wiley‐Liss, Inc. Microsurgery, 2007.