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Spleen autotransplantation. Morphological and functional follow‐up after spleen autotransplantation in mice: A research summary
Author(s) -
Miko Iren,
Brath Endre,
Nemeth Norbert,
Furka Andrea,
Sipka Sandor,
Peto Katalin,
Serfozo Jozsef,
Kovacs Judit,
Imre Sandor,
Benko Ilona,
Galuska Laszlo,
Sipka Sandor,
Acs Geza,
Furka Istvan
Publication year - 2007
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.20362
Subject(s) - autotransplantation , spleen , medicine , beagle , splenocyte , splenectomy , regeneration (biology) , stem cell , transplantation , surgery , pathology , immunology , biology , microbiology and biotechnology , genetics
In 1986, we started the research on spleen surgery aimed at saving the splenic mass after its traumatic injury, with elaboration of special resection and autotransplantation techniques. The researches started on mongrel dogs and were continued on inbred mice and beagle dogs with complex histological, imaging, and laboratory investigations, following‐up the function and the regeneration of autotransplanted spleen chips. Performing research on mice provided more immunological methods, such as lymphocyte subsets, immunoglobulin levels, and monitoring the phagocytic functions. Researches showed evidence also on the presence of apoptosis, furthermore, stem cell studies on regeneration and functional restoration of the spleen chips are in progress. Our results contributed to two multidisciplinary guidelines in Hungary: (1) One of them is under preparation and underlines the importance of spleen saving methods after traumatic splenic injury; (2) The second guideline shows that hemorheological changes can be early indicators of the increased sensitivity to postsplenectomy infections. © 2007 Wiley‐Liss, Inc. Microsurgery 2007.