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Rutin in rat liver ischemia/reperfusion injury: Effect on DDAH/NOS pathway
Author(s) -
Lanteri Raffael,
Acquaviva Rosaria,
Di Giacomo Claudia,
Sorrenti Valeria,
Li Destri Giovanni,
Santangelo Marco,
Vanella Luca,
Di Cataldo Antonio
Publication year - 2007
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.20345
Subject(s) - rutin , medicine , nitric oxide , enos , ischemia , reperfusion injury , oxidative stress , pharmacology , nitric oxide synthase , endothelial nos , anesthesia , endocrinology , antioxidant , biochemistry , chemistry
Nitric oxide (NO) plays a key role in the relationship between microcirculatory disorders and I/R injuries. Our results demonstrated a significant modification in the hepatic function of I/R rats compared with the control group; treatment with rutin reported hepatic damage markers to control value. Levels of plasmatic and hepatic thiol groups decreased in the I/R untreated group, and this decrease was inhibited by rutin treatment. In addition, we observed an increase in the iNOS expression in I/R group compared with control and rutin administration attenuated this increase; in post‐ischemic reperfused rutin‐treated rats there was a significant increase in eNOS expression compared with the I/R untreated group. In the same experimental conditions an increase in DDAH 1 expression was observed in I/R group only; rutin treatment also counteracted this increased expression. These data suggest that rutin treatment could be useful for preventing oxidative damage associated with hepatic post‐ischemic reperfusion injury. © 2007 Wiley‐Liss, Inc. Microsurgery 2007.
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