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Pulse doppler and M‐mode to assess viability of cardiac allografts using heterotopic femoral heart transplantation in rats
Author(s) -
Gordon Chad R.,
Lefebvre Daniel R.,
Matthews Martha S.,
Strande Louise F.,
Marra Steven W.,
Guglielmi Massimiliano,
Skaf Jad,
Hollenberg Steven M.,
Hewitt Charles W.
Publication year - 2007
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.20343
Subject(s) - medicine , heart transplantation , transplantation , doppler echocardiography , surgery , cardiology , radiology , blood pressure , diastole
Noninvasive assessment of heterotopic heart transplants using Doppler echocardiography was first described in two patients by Allen at Stanford in 1981. Since then, numerous experiments studying heterotopic heart transplantation in humans and large animals have confirmed its utility by employing either an intra‐abdominal or cervical model. In rats, however, prior research investigating intra‐abdominal heterotopic hearts has showed echocardiography to be ineffective. We have recently developed a new technique for heterotopic femoral heart transplantation in rats, which employs the novel use of trans‐femoral echocardiography. Therefore, our goal was to re‐examine the efficacy of echocardiography for detection of graft rejection. © 2007 Wiley‐Liss, Inc. Microsurgery, 2007.