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Diverse types of epineural conduits for bridging short nerve defects. An experimental study in the rabbit
Author(s) -
Ignatiadis Ioannis A.,
Yiannakopoulos Christos K.,
Barbitsioti Antonia D.,
Avram Adrian M.,
Patralexis Haralambos G.,
Tsolakis Charilaos K.,
Papalois Apostolos E.,
Xenakis Theodoros H.,
Beris Alexandros E.,
Soucacos Panayiotis N.
Publication year - 2007
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.20313
Subject(s) - medicine , regeneration (biology) , sciatic nerve , peripheral nerve , anatomy , electromyography , immunohistochemistry , bridge (graph theory) , peripheral , immunocytochemistry , pathology , surgery , biology , psychiatry , microbiology and biotechnology
In this study the process of peripheral nerve regeneration through an epineural flap conduit was examined using four groups of 126 New Zealand rabbits. There were three study groups (A, B, and C) and 1 control group (D). A 10‐mm long sciatic nerve defect was bridged either with 3 variations of an epineural flap (Groups A, B, and C) or with a nerve autograft (Group D). Animals from all groups were examined 21, 42, and 91 days postoperatively to evaluate nerve regeneration employing light microscopy and immunocytochemistry. Nerve regeneration was studied in transverse sections at 3, 6, and 9 mm from the proximal stump. The gastrocnemius muscle contractility was also examined prior to euthanasia at 91 days postsurgery in all groups using electromyography. Immunohistochemical, histochemical and functional evaluation showed the presence of nerve regeneration resembling the control group D, especially in group A, where an advancement epineural flap was used. In this experimental model an epineural flap can be used to bridge a nerve defect successfully. © 2007 Wiley‐Liss, Inc. Microsurgery, 2007.