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Regulatory dendritic cells modulate immune responses via induction of T‐cell apoptotic death
Author(s) -
Liang Xiaoyan,
Chen Zongyou,
Fung John J.,
Qian Shiguang,
Lu Lina
Publication year - 2006
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.20205
Subject(s) - medicine , apoptosis , programmed cell death , immunology , immune system , dendritic cell , population , monoclonal antibody , cell , lymphatic system , microbiology and biotechnology , immune tolerance , t cell , in vivo , cancer research , antibody , biology , biochemistry , genetics , environmental health
We describe a regulatory lymphoid dendritic cell (LDC) population propagated from mouse liver nonparenchymal cells (NPC) in IL‐3 and anti‐CD40 monoclonal antibody that are phenotypically mature, and induce T‐cell hyporesponsiveness by promoting T‐cell apoptotic death, which is partially caspase‐dependent, but is unlikely to be mediated by soluble factor(s). In vivo administration of liver LDC significantly prolonged the survival of vascularized cardiac allografts in an alloantigen‐specific manner. This is associated with enhanced T‐cell death in secondary lymphoid organs. © 2006 Wiley‐Liss, Inc. Microsurgery 26: 21–24, 2006.