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Effect of phosphate concentration in buffered irrigating solutions on arterial thrombosis
Author(s) -
Brown David M.,
Kania Norbert,
Lantieri Laurent A.,
Pasia E. Neil,
Khouri Roger K.
Publication year - 1995
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920161111
Subject(s) - thrombosis , medicine , saline , phosphate , potassium , magnesium , cardiology , surgery , biochemistry , chemistry , organic chemistry
The concentration of phosphate in buffered saline irrigation solutions was evaluated for its effect upon the incidence of arterial thrombosis. A rabbit thrombosis model of combined intimal abrasion and twisted pedicle in the rabbit central ear artery was used. Higher concentrations of phosphate (20 mM) in normal saline yielded a lower thrombosis rate at 7 days postoperatively (50%) in comparison to 5 mM phosphate (89% thrombosis rate; P <0.05). A standard phosphate‐buffered salt solution (Dulbecco's; 9.5 mM phosphate with potassium, calcium, and magnesium salts) also had a high thrombosis rate (91%). This study demonstrates that subtle variations in the irrigation solution can have profound effects upon arterial thrombosis. © 1995 Wiley‐Liss, Inc.