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Experimental microvenous thrombosis following anastomosis with a knotted suture
Author(s) -
Tonken Heidi P.,
Zhang Feng,
Yim Kenneth K.,
Gencosmanoglu Reha,
Sudekum Anthony E.,
CampagnaPinto Dante,
Newlin Leonard,
Buncke Harry J.,
Lineaweaver William C.
Publication year - 1995
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920160211
Subject(s) - medicine , anastomosis , thrombosis , surgery , fibrous joint , knot (papermaking) , suture line , engineering , chemical engineering
An experimental model for producing venous thrombosis was developed in end‐to‐end anastomoses of femoral veins in rats. The anastomoses were performed using a suture (9–0 suture‐70 μm needle) with a knot 1 cm from the needle. The knot was formed by making either six or eight half‐hitches in one throw of the suture. Vessel patency was assessed through the direct “milking test” at 20 min and 24 hrs. The incidence of thrombosis when using one knot with six half‐hitches ranged from 20% to 40% and with eight half‐hitches, from 50% to 70%. The incidence of femoral vein thrombosis varied directly with the presence and size of the knot. In this model, thrombosis was induced by exaggerating vessel injuries that may occur when performing routine microvascular anastomoses. This study demonstrates a reproducible thrombogenic model which mimics clinical practice and may be used to study the effects of local and systemic antithrombogenic agents. © 1995 Wiley‐Liss, Inc.