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Primary common bile duct anastomosis in the rat using microsurgical techniques
Author(s) -
Chansmorn Chuphan,
Lineaweaver William C.,
Tonken Heidi,
Zhang Feng,
CampagnaPinto Dante,
Newlin Leonard,
Yim Kenneth,
Buncke Harry J.
Publication year - 1994
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920151207
Subject(s) - medicine , anastomosis , microsurgery , surgical anastomosis , surgery , primary (astronomy) , bile duct , common bile duct , general surgery , physics , astronomy
In a rat model, we attempted to describe the natural healing course of the common bile duct (CBD) after primary microsurgical repair. Fifty‐three rats were divided into experimental groups with CBD microsurgical anastomoses and control groups with CBD mobilization and ligation. Examination of three experimental groups at 1 week, 1 month, and 3 months showed evolving inflammation and stricture changes with eventual patent, healed ducts in 92% of animals at the end of 3 months following transection and repair. There were no histologic abnormalities in the livers. There were fibrotic ducts and hepatic stasis and cirrhosis changes in the control group with CBD ligation. This study demonstrates that microsurgical techniques can achieve successful primary biliary repair in the rat. © 1994 Wiley‐Liss, Inc.