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Electrophysiological evaluation of the effects of naftidrofuryl on skeletal muscle reinnervation in the rat
Author(s) -
PécotDechavassine Monique,
Mira JeanClaude
Publication year - 1994
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920150206
Subject(s) - reinnervation , medicine , denervation , electrophysiology , sciatic nerve , tibial nerve , anesthesia , gastrocnemius muscle , nerve injury , anatomy , neuromuscular junction , sprouting , skeletal muscle , neuroscience , biology , botany , stimulation
The effects of naftidrofuryl on the reinnervation of the rat gastrocnemius muscle after its denervation by localized freezing of the sciatic nerve were tested with electrophysiological techniques. Daily intraperitoneal injections of 30mg/kg of naftidrofuryl do not increase the rate of axonal regeneration since early signs of reinnervation appeared as in controls around the 10th day after surgery. However, axonal sprouting is markedly increased since the percentage of muscle fibers with polyneuronal innervations was almost twice as high as in controls at the 15 and 21 day postoperative stages. The promoting effects of naftidrofuryl on polyneuronal innervation which gives rise to a redundant innervation during the first period of reinnervation constitutes an improvement of motor function which might be efficient for treatment of nerve injury and neuropathies. © 1994 Wiley‐Liss, Inc.