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Experimental study of the osteogenic capacity of periosteal allografts: A preliminary report
Author(s) -
Liu Jian Yin,
Wang Dan,
Cheng Hsu Hsi
Publication year - 1994
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920150202
Subject(s) - medicine , revascularization , surgery , radiography , myocardial infarction
A total of 16 rabbits were used in this investigation. Beijing long‐eared white rabbits served as donors and immunologically incompatible Chinchilla rabbits as recipients. Periosteal flaps were stripped from the femurs of 8 donor rabbits and implanted into the muscles of both thighs of 8 recipients. Revascularization of the grafts was done only on the left side. Immunosuppressants were administered orally beginning the day of surgery. The animals were observed for 1–4 months. A series of radiography, histomorphology, fluochrome labelling, and electron microscopic examinations were performed. The results demonstrated that all of the revascularized periosteal allografts had new bone formation (8/8), while the non‐revascularized periosteal allografts had none (0/8). The difference in the rate of new bone formation between the two groups was statistically significant. © 1994 Wiley‐Liss, Inc.