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Inside‐out vein graft promotes improved nerve regeneration in rats
Author(s) -
Wang KaiKai,
Costas Paul D.,
Bryan David J.,
Jones David S.,
Seckel Brooke R.
Publication year - 1993
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920140914
Subject(s) - medicine , vein , regeneration (biology) , nerve repair , anastomosis , surgery , peripheral nerve , bridge (graph theory) , anatomy , microsurgery , biology , microbiology and biotechnology
Vein grafts have been used both experimentally and clinically to bridge gaps in peripheral nerves. This study describes a modification of the vein graft technique in which vein graft conduits are pulled inside‐out before anastomosis with proximal and distal nerve stumps. This technique creates an autogenous vein conduit with the collagen‐rich adventitial surface exposed to the regenerating axons. The inside‐out technique is a fast and simple modification of the standard vein graft technique and produces an accelerated rate of nerve regeneration and significantly earlier myelination compared with the results obtained from the use of polyethylene nerve guides and standard vein graft conduits. © 1993 Wiley‐Liss Inc.