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Carotid blood flow in anesthetized rats: Effects of carotid ligation and anastomosis
Author(s) -
GarcíaVillalón Angel Luis,
Roda José María,
Alvarez Fernando,
Gómez Bernardino,
Diéguez Godofredo
Publication year - 1992
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920130513
Subject(s) - medicine , anastomosis , ligation , carotid arteries , blood flow , arteriovenous anastomosis , anesthesia , surgery , cardiology
An experimental model was developed for continuous measurement of the common carotid blood flow, in the anesthetized rat, with an electromagnetic flowmeter. The mean carotid blood flow for 41 rats averaged 3.2 ± 0.2 ml/min at an average mean arterial pressure of 101 ± 2.5 mm Hg and arterial pO 2 of 106 ± 3.4 mm Hg, pCO 2 of 38 ± 1.2 mm Hg, and pH of 7.36 ± 0.02. This model allowed short‐ and long‐term carotid hemodynamic changes to be recorded after contralateral carotid ligation or end‐to‐side carotid anastomosis. After ligation of the contralateral carotid, blood flow through the intact carotid increased 25% (at about 1 week) and 45% (at about 5‐6 months), whereas, after anastomosis, carotid blood flow increased 76% and 89% at periods comparable to those after ligation. Arterial pressure and gases did not change throughout the experimental periods. Probable mechanisms involved in these carotid hemodynamic changes are discussed. © Wiley‐Liss, Inc.