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Morphologic and morphometric analyses of rat femoral arteries after crush injury
Author(s) -
Chen LongEn,
Seaber Anthony V.,
Glisson Richard R.,
Mikat Eileen M.,
Urbaniak James R.
Publication year - 1991
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920120607
Subject(s) - thrombus , medicine , crush injury , internal elastic lamina , intimal hyperplasia , thrombosis , amputation , anatomy , platelet , surgery , artery , smooth muscle
Replantation after crush amputation has a relatively low success rate. An arterial crush injury was produced in rats under a range of pressure (8.5 to 2,551 g/mm 2 ) and durations (10 to 60 minutes). The degrees of vessel injury and thrombus formation were evaluated as functions of both crush force and duration, and the healing process was followed for 8 weeks. Crushing resulted in morphologic damage to the arterial wall but did not impair patency. Damage was directly proportional to crush pressure and duration. Intimal denudation caused flat platelet adhesion but no thrombus formation or thrombosis. Re‐endothelialization was completed by 2 weeks. Intimal hyperplasia appeared at 1 week and consisted of endothelia in the most luminal layers and smooth muscle in the deeper layers. The internal elastic lamina was intact in all specimens and was thought to minimize platelet aggregation on the arterial wall after denudation of the intima.