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Experience in rat pancreas transplantation at meikai university
Author(s) -
Nozawa Masumi,
Otsu Ichiro
Publication year - 1990
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920110212
Subject(s) - medicine , pancreas transplantation , transplantation , pancreas , diabetes mellitus , urinary system , glucagon , endocrine system , somatostatin , diabetic nephropathy , urine , endocrinology , amylase , urology , gastroenterology , insulin , kidney transplantation , hormone , enzyme , biology , biochemistry
Abstract A review of rat pancreatic transplantation conducted at Meikai University is presented. It was found that pancreas transplantation normalized the endocrine based metabolic disturbances of diabetes. Arginine‐induced serum insulin, glucagon, and somatostatin responses in the grafted pancreas were similar to those in normal pancreas. Urine amylase was found to be a more sensitive marker in graft rejection as compared with blood glucose using a urinary drainage model. The value of pancreas transplantation in diabetic nephropathy was dependent upon the timing of the transplantation; performed early in the course of diabetes (less than 4 months, post‐diabetes), it was able to reverse the nephropathy.