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Sequential changes of noradrenaline content of vein grafts in rats: Quantitative estimation by high‐performance liquid chromatography using electrochemical detection
Author(s) -
Hukki Jyri,
Attila Martti,
Haikala Heimo,
Castren Maaret,
Lähteenmäki Tapani,
Smitten Karl V.,
Waris Timo
Publication year - 1989
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920100207
Subject(s) - medicine , vein , abdominal aorta , inferior vena cava , vena cava , denervation , renal vein , aorta , surgery , anesthesia , kidney
Supradiaphragmatic inferior vena cava was transplanted end‐to‐end into the abdominal aorta of 11 ‐week‐old rats of the same inbred strain and same litter using microvascular technique. The grafts were removed 3 days, 4,8,16, and 35 weeks postoperatively, and their noradrenaline (NA) content was estimated by high‐performance liquid chromatography using electrochemical detection. The amount of NA was significantly lower (P <.001) in all vein grafts as compared to nontransplanted vena cava. The substantial decrease of NA in the vein grafts throughout the observation period indicates a persistent denervation of the transplant.