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Long‐term studies of pancreas allotransplantation in experimental diabetes mellitus
Author(s) -
Lee Sun,
Scott Michael H.,
Yancey Diane,
Allen Jennifer,
Chang Eil Sung,
Chisari Francis,
Moossa A. R.
Publication year - 1988
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920090312
Subject(s) - medicine , allotransplantation , creatinine , diabetes mellitus , blood urea nitrogen , transplantation , islet , nephrotoxicity , urology , regimen , body weight , atrophy , endocrinology , alloxan , surgery , kidney
Pancreaticoduodenal (PD) allografts (Brown Noway‐alloxan‐diabetic rats, n = 190) were treated with cyclosporin A (Cy‐A) 10 mg/kg/daily and compared with nondiabetics with Cy‐A treatment (n = 55), diabetics (n = 50), and diabetics with Cy‐A treatment (n = 45). Body weight, blood sugar, blood insulin, blood urea nitrogen (BUN), and creatinine were monitored periodically; there were marked elevations of BUN and creatinine levels, indicating probable nephrotoxicity of Cy‐A at this dosage. Some islet cell atrophy in the PD allografts was noted at the conclusion of the study. With respect to the immunosuppressive effect of Cy‐A in alloxan diabetic rats, Brown Norway PD transplants into Lewis rats were successful and free of rejection for as long as 15 months post‐transplantation. The body weight of these PD transplanted rats, however, never approached values representative of the nondiabetic rats. In our experience, the PD allograft model is acceptable in the clinical situation, particularly in children if the microsurgical technique is mastered and if the Cy‐A regimen is used in combination with other immunosuppressant(s).