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The effects of intravenous prostacyclin in a model of microsurgical thrombosis
Author(s) -
Bailes Julian E.,
Quigley Matthew R.,
Kwaan Hau C.,
Nishiura Bing R.,
Cerullo Leonard J.,
Lastre Clara
Publication year - 1988
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920090103
Subject(s) - medicine , prostacyclin , thrombosis , microsurgery , surgery , anesthesia
Numerous agents have been administered in an attempt to achieve specific biochemical antiplatelet activity. A model of microsurgical trauma was utilized to create a nonocclusive thrombus, similar to what occurs in the postoperative period. Prostacyclin (PGI 2 ) was given in a high intravenous dose which caused in vitro inhibition of platelet aggregation in rats and rabbits. Although hematological and cardiovascular side effects of PGI 2 were tolerated, in vivo platelet thrombus formation persisted and constituted 25–75% of the postoperative thrombus. Even though platelets were inhibited by PGI 2 , other significant stimuli remained at the site of injury for activation and participation of platelets in the formation of a thrombus.