The effects of intravenous prostacyclin in a model of microsurgical thrombosis | Zendy

Bailes Julian E. | Zendy; Quigley Matthew R. | Zendy; Kwaan Hau C. | Zendy; Nishiura Bing R. | Zendy; Cerullo Leonard J. | Zendy; Lastre Clara | Zendy

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The effects of intravenous prostacyclin in a model of microsurgical thrombosis

Author(s) -

Bailes Julian E.,

Quigley Matthew R.,

Kwaan Hau C.,

Nishiura Bing R.,

Cerullo Leonard J.,

Lastre Clara

Publication year - 1988

Publication title -

microsurgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.031

H-Index - 63

eISSN - 1098-2752

pISSN - 0738-1085

DOI - 10.1002/micr.1920090103

Subject(s) - medicine , prostacyclin , thrombosis , microsurgery , surgery , anesthesia

Numerous agents have been administered in an attempt to achieve specific biochemical antiplatelet activity. A model of microsurgical trauma was utilized to create a nonocclusive thrombus, similar to what occurs in the postoperative period. Prostacyclin (PGI 2 ) was given in a high intravenous dose which caused in vitro inhibition of platelet aggregation in rats and rabbits. Although hematological and cardiovascular side effects of PGI 2 were tolerated, in vivo platelet thrombus formation persisted and constituted 25–75% of the postoperative thrombus. Even though platelets were inhibited by PGI 2 , other significant stimuli remained at the site of injury for activation and participation of platelets in the formation of a thrombus.

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