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Allogeneic heart‐lung transplantation in mice
Author(s) -
Chang Eil Sung,
Chisari Francis V.,
Lee Sun
Publication year - 1987
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920080206
Subject(s) - medicine , palpation , lung , heart lung transplantation , surgery , heart transplants , abdomen , transplantation , graft rejection , heart transplantation
Using a simpler technique for mouse heart and lung transplantation, a histological comparison was made between groups of syngeneic and allogeneic transplants. The initial high postoperative mortality encountered was due to technical difficulty and as the operative technique improved, mortality lessened. While direct palpation of the abdomen is the key means in the detection of graft rejection, there is no practical determination of such graft rejection other than histological clarification. Doppler tracing also is not a sensitive method for detecting rejection. The transplanation technique in this study compares the time of rejection of heart and lung transplants more legitimately.