Reversibility of graft rejection following a short cyclosporin‐a administration 5 days after grafting | Zendy

Mazzoni Giuseppe | Zendy; Mazzoni Pietro | Zendy

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Reversibility of graft rejection following a short cyclosporin‐a administration 5 days after grafting

Author(s) -

Mazzoni Giuseppe,

Mazzoni Pietro

Publication year - 1986

Publication title -

microsurgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.031

H-Index - 63

eISSN - 1098-2752

pISSN - 0738-1085

DOI - 10.1002/micr.1920070303

Subject(s) - medicine , grafting , surgery , graft rejection , olive oil , transplantation , chemistry , organic chemistry , polymer , food science

The aim of this research was to investigate whether cyclosporin‐A (Cy‐A) could exert its action on graft rejection in progress. For this purpose, heartlung grafting was performed in a strong hystoincompatible combination of rats (BN/LEW). In one group of animals, Cy‐A was administered at the dose of 15 mg/kg daily for 10 days starting on the 5th day after grafting. In a control group only olive oil was administered. Five of six animals treated with Cy‐A showed a graft survival over 4 weeks and in two cases it was over 2 months when they were killed.

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