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Histopathology of microvenous repair
Author(s) -
Morecraft Robert,
Blair William F.,
Chang Laurette
Publication year - 1985
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920060406
Subject(s) - medicine , histopathology , pathology
The histopathology of microvascular repair was investigated in the femoral vein of the rat. Previous microvascular repair studies have primarily involved arteries, giving little insight to similar processes in veins. In our study, 36 rats with an average weight of 440 gm were randomly assigned to experimental groups of 1 hour, 24 hours, 2 weeks, and 4 weeks after repair. Histological evaluation of the suture site included the use of light, scanning electron, and transmission electron microscopy. Endothelial loss was observed in all 1‐hour specimens. Extensive inflammatory response appeared in 2‐hour specimens. Re‐endotheliolization of the intima was achieved in all animals by the 2‐week time interval. At 4 weeks, the animals exhibited evidence of medial regeneration of smooth muscle cells. This was predominantly occurring between adjacent suture sites. Minimal subintimal hyperplasia was localized at the suture site itself in both 2‐ and 4‐week specimens.