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Vascularization of tricalcium phosphate, an artificial bone substitute: Preliminary observations
Author(s) -
Angel Michael F.,
Swartz William M.,
Ramasastry Sai S.,
Brown Mary Lynn,
Hanley Edward N.,
Herbert David L.
Publication year - 1985
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920060309
Subject(s) - medicine , resorption , implant , histology , biocompatible material , bone resorption , anatomy , dentistry , surgery , biomedical engineering , pathology
Tricalcium phosphate (TCP), a biodegradable artificial bone substitute, was used to study the following questions: (i) can TCP be vascularized; (ii) do ectopically placed implants have osteoinductive capacity; and (iii) does vascularization affect implant resorption? Implants were placed in dogs in several areas: (i) subcutaneous controls; (ii) wrapped with latissimus dorsi muscle; (iii) wrapped in omentum; (iv) saphenous and thoracodorsal av pedicles threaded through implant. Prior to harvest, animals were given tetracycline and implants were harvested at 3, 6, and 9 weeks. Microfil was injected prior to sacrifice and specimens were xeroradiographed. Histology and computerized axial tomography were obtained. From this study, we conclude that (1) TCP can be vascularized; (2) the most effective method of vascularization was by an AV pedicle threaded through the implant; (3) vascularized implants did not have osteoinductive properties per se, and (4) in the time observed no difference in implant resorption was demonstrated between the test groups.