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Immediate and prolonged effects of dihydroergocryptine after experimental vascular microsurgery
Author(s) -
Merle Agrügé M.,
Restrepo Y.,
Benharkate M.,
Legeai J.
Publication year - 1985
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920060110
Subject(s) - medicine , replantation , agonist , partial agonist , peripheral , blood flow , ischemia , microsurgery , anesthesia , hemodynamics , pharmacology , surgery , receptor
An animal model of limb replantation has been utilized in order to evaluate the effects of dihydroergocryptine (DHEC, 0.1 mg/kg I.V.) on arterial and peripheral tissular blood flows after reperfusion. DHEC is a partial agonist of adrenergic receptors and is therefore liable to exert an action on arteriovenous shunts that remain abnormally opened after ischaemia. DHEC showed important efficacy in this model, increasing, in low doses, blood flow in sutured artery and peripheral tissue.