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The effects of preservation on microvascular vein grafts in rats
Author(s) -
Razaboni Rosa M.,
Greco M. Alba,
Harper Alice D.,
Shaw William W.,
Ballantyne Donald L.
Publication year - 1981
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920030202
Subject(s) - medicine , lumen (anatomy) , thrombosis , endothelium , microsurgery , vein , surgery , femoral vein , internal elastic lamina , deep vein , anatomy , artery
Segments 15 mm in length were excised from the femoral veins of rats and preserved by refrigeration at 4 C in lactated Ringer's solution for periods up to 21 days. The findings show that veins can be preserved for up to seven days and successfully grafted to recipients. Although there was some success in preserving vein segments for more than seven days, a high rate of thrombosis occurred after implantation in the recipients. It is generally accepted that damaged endothelium causes thrombosis. The light and electron microscopic observations in this study, however, suggest that the condition of the endothelium may not be the only important factor in the patency of small vessels. A thickened and prominent elastic lamina may also play a role in keeping the lumen open.